HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2217771Generated: November 2, 2026
Potassium Carbonate → 3-cyclopentyl-1-methyl-2-pyridin-2-yl-1H-indole-6-carboxylic acid methyl ester
https://huagongshe.com/reaction/2217771
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 3-Amino-4-chlorobenzoate | HCID 593055 | — |
| Reactant | 2-(Cyclopentylethynyl)pyridine | HCID 21916613 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Catalyst | 1,1'-Bis(di-tert-butylphosphino)ferrocene | HCID 71310544 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 3-cyclopentyl-1-methyl-2-pyridin-2-yl-1H-indole-6-carboxylic acid methyl ester | HCID 58720916 | — |
Reaction Steps
A 100 mL three neck flask equipped with a thermocouple, condenser and stir bar was purged with argon. 3-Amino-4-chlorobenzoic acid methyl ester (5.0 g, 26.94 mmol), 2-cyclopentylethynyl-pyridine (5.528 g, 32.33 mmol), Pd(OAc)2 (181 mg, 0.81 mmol), DtBPF (767 mg, 1.62 mmol), K2CO3 (9.29 g, 67.35 mmol) and NMP (25 mL) were then charged. The reaction was heated to 130° C. and monitored by HPLC. The reaction was complete after 6 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07408076B2 |
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| Source dataset | uspto-grants-2008_08 |
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| ORD ID | ord-317eb09d561540c498635d25d42fc5a2 |
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| Source note | uspto-grants-2008_08 |
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