(2R)-3-aminopropane-1,2-diol → HCID 11223072, compound

HRID 2217798Notes

Reaction equation

HRID 2217798 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:22])[C:8]=2[NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[N:3]=1.[NH2:23][CH2:24][C@@H:25]([OH:28])[CH2:26][OH:27]>>[Cl:22][C:7]1[C:8]([NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH:23][CH2:24][C@@H:25]([OH:28])[CH2:26][OH:27])[CH:11]=[CH:10]2

Participants

3

Reactant 2

HCID 6994409(2R)-3-aminopropane-1,2-diolHCID 86012996N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide

Product 1

HCID 11223072HCID 11223072, compoundYield 8.6%

Procedure

Prepared according to the method of example 2, using N-(2,6-dichloro-5-quinolinyl)-cyclohexaneacetamide (Example 1 (a)) (200 mg) and 3-amino-(2R)-1,2-propanediol (655 mg). Purification (SiO2, dichloromethane:methanol 9:1 as eluant) gave the title compound (20 mg).

Workup

  1. customPrepared
  2. customPurification (SiO2, dichloromethane:methanol 9:1 as eluant)

Sources & evidence

ORD record
ord-191a9c0a740b4a3caadd5caa2acfa02b
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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