HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2217829Generated: October 30, 2026
Methylamine → N-[6-Chloro-2-[(3R)-3-(methylamino)-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide
https://huagongshe.com/reaction/2217829
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | N-[6-Chloro-2-[(3S)-3-[(methylsulfonyl)oxy]-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide | HCID 86609739 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[6-Chloro-2-[(3R)-3-(methylamino)-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide | HCID 11269597 | — |
Reaction Steps
To a 10 mL vial was added N-[6-Chloro-2-[(3S)-3-[(methylsulfonyl)oxy]-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide (Example 33(a)) (225 mg) and 8M methylamine in ethanol (6 mL). The vial was sealed and heated at 80° C. for 120 minutes within a microwave. The solvent was removed under vacuum and purified (SiO2, ammonia:methanol:dichloromethane, 1:2:97 as eluant) to afford the titled compound (0.033 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07408065B2 |
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| Source dataset | uspto-grants-2008_08 |
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| ORD ID | ord-4f1e934f0d944a38b5eb091b9701b196 |
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| Source note | uspto-grants-2008_08 |
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