Ethanolamine → HCID 59768616, compound

HRID 2217833Notes

Reaction equation

HRID 2217833 reaction equation
[Cl:1][C:2]1[C:3]([NH:22][C:23](=[O:31])[CH2:24][CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:12]1[CH2:16][CH2:15][C@@H:14](OS(C)(=O)=O)[CH2:13]1)[CH:6]=[CH:5]2.[CH2:32]([CH2:34][NH2:35])[OH:33]>>[Cl:1][C:2]1[C:3]([NH:22][C:23](=[O:31])[CH2:24][CH:25]2[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]2)=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:12]1[CH2:16][CH2:15][C@H:14]([NH:35][CH2:34][CH2:32][OH:33])[CH2:13]1)[CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 700EthanolamineHCID 86609740N-[6-Chloro-2-[(3R)-3-[(methylsulfonyl)oxy]-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide

Product 1

HCID 59768616HCID 59768616, compound

Procedure

Prepared according to the method of example 33(b), using N-[6-Chloro-2-[(3R)-3-[(methylsulfonyl)oxy]-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide (Example 35(a)) (0.2 g) and ethanolamine (0.8 mL) to afford the title compound (0.068 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e6da748bf0714b298118ebfdfa73830e
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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