(3S)-(-)-3-Aminopyrrolidine → HCID 11474056, compound

HRID 2217835Notes

Reaction equation

HRID 2217835 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:22])[C:8]=2[NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[N:3]=1.[NH:23]1[CH2:27][CH2:26][C@H:25]([NH2:28])[CH2:24]1>>[NH2:28][C@H:25]1[CH2:26][CH2:27][N:23]([C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[C:7]([CH3:22])[C:8]=3[NH:12][C:13](=[O:21])[CH2:14][CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[N:3]=2)[CH2:24]1

Participants

3

Reactant 2

HCID 1519351(3S)-(-)-3-AminopyrrolidineHCID 86013006HCID 86013006, compound

Product 1

HCID 11474056HCID 11474056, compoundYield 68.7%

Procedure

Prepared according to the method of example 30, using N-(2-Chloro-6-methyl-5-quinolinyl)-cyclohexaneacetamide (Example 15(a)) (0.2 g) and (3S)-3-pyrrolidinamine (0.163 g) which after recrystallisation from ethanol afforded the title compound (0.159 g).

Workup

  1. customPrepared
  2. customafter recrystallisation from ethanol

Sources & evidence

ORD record
ord-a3e8e6b723d345a680dda9c633248165
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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