Tert-butyl 3-aminopropanoate hydrochloride → HCID 68810268, compound

HRID 2217838Notes

Reaction equation

HRID 2217838 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:22])[C:8]=2[NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[N:3]=1.Cl.[C:24]([O:28][C:29](=[O:33])[CH2:30][CH2:31][NH2:32])([CH3:27])([CH3:26])[CH3:25]>>[Cl:22][C:7]1[C:8]([NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH:32][CH2:31][CH2:30][C:29]([O:28][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:33])[CH:11]=[CH:10]2

Participants

3

Reactant 2

HCID 16218890Tert-butyl 3-aminopropanoate hydrochlorideHCID 86012996N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide

Product 1

HCID 68810268HCID 68810268, compoundYield 28.4%

Procedure

Prepared according to the method of example 7 (a), using N-(2,6-dichloro-5-quinolinyl)-cyclohexaneacetamide (Example 1 (a)) (400 mg) and β-alanine tert-butyl ester hydrochloride (1.6 g) to afford the sub-title compound (150 mg).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-309dd820a8494d24a6d64b03900d1891
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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