反应详情

温度

100 °C

A stirred suspension of 2,6-dichloro-N-(cyclohexylmethyl)quinoline-5-carboxamide (Example 43 (a)) (250 mg) and N,N′-dimethyl-1,3-propanediamine (0.80 mL) in acetonitrile (3 mL) was heated at 100° C. in a microwave for 2 hours after which it was cooled to room temperature and concentrated. The residue was purified by recrystallisation (methanol:ethyl acetate). The resultant product was converted to the dihydrochloride salt by treatment with hydrochloric acid (4M in 1,4-dioxane). Recrystallisation (methanol/ethyl acetate) afforded the title compound as a solid (110 mg).

1. temperaturewas cooled to room temperature
2. concentrationconcentrated
3. customThe residue was purified by recrystallisation (methanol:ethyl acetate)
4. customRecrystallisation (methanol/ethyl acetate)