Hydrochloric Acid → HCID 68809668, compound

Participants

Reaction Steps

A mixture of 6-Chloro-N-(cyclohexylmethyl)-2-[(3S)-3-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]-1-pyrrolidinyl]-5-quinolinecarboxamide (Example 50(a)) (0.16 g) in 1,4-dioxane (1 mL) was treated with 4M HCl in 1,4-dioxane (1 mL) and stirred at room temperature for 16 hours. The reaction mixture was concentrated to dryness. Purification (HPLC, Symmetry—0.1% aqueous trifluoroacetic acid/acetonitrile) followed by conversion of the resultant product to its hydrochloride salt by treatment with hydrochloric acid (4M in 1,4-dioxane) afforded the title product (0.05 g).

Provenance & Evidence