HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3S)-Piperidin-3-amine--hydrogen chloride (1/2) → HCID 59768630, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3S)-Piperidin-3-amine--hydrogen chloride (1/2) | HCID 16218278 | — |
| Reactant | 2,6-dichloro-N-(cyclohexylmethyl)-5-quinolinecarboxamide | HCID 86013022 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 59768630 | HCID 59768630 | 40.4% |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
A stirred suspension of 2,6-dichloro-N-(cyclohexylmethyl)quinoline-5-carboxamide (Example 43(a)) (250 mg), (3S)-3-piperidinamine dihydrochloride (260 mg) and tetrabutylammonium bromide (20 mg) in acetonitrile (2 mL) was heated at 130° C. in a microwave for 90 minutes after which it was cooled to room temperature and concentrated. The residue was purified by chromatography (SiO2, dichloromethane:methanol:ammonia in methanol (7 M) 96:3:1 as eluant) and subsequent recrystallisation (acetonitrile) gave the title compound as a solid (120 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07408065B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-98d1725d0f1f423fa1488e031f35f95e |
| Source note | uspto-grants-2008_08 |