Hydrochloric Acid → 6-Chloro-N-(cyclohexylmethyl)-2-[(3S)-3-[(2-hydroxyethyl)amino]-1-piperidinyl]-5-quinolinecarboxamide

Participants

Reaction Steps

Prepared according to the method of example 50(b) using 6-chloro-N-(cyclohexylmethyl)-2-[(3S)-3-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]-1-piperidinyl]-5-quinolinecarboxamide Example 52(a)) (190 mg) and hydrochloric acid (4M in 1,4-dioxane) (2.0 mL). Purification (SiO2, dichloromethane:methanol:ammonia in methanol (7 M) 96:3:1) and subsequent recrystallisation (acetonitrile) gave the title compound as a solid (53 mg).

Provenance & Evidence