Ethanolamine → HCID 11292966, compound

HRID 2217851Notes

Reaction equation

HRID 2217851 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[C:7]([N:12]3[CH2:15][CH:14]([NH:16][CH2:17][CH2:18][O:19]S(C)(=O)=O)[CH2:13]3)[CH:6]=[CH:5][C:4]=2[C:3]=1[C:24]([NH:26][CH2:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1)=[O:25].C(CN)O>>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[C:7]([N:12]3[CH2:15][CH:14]([NH:16][CH2:17][CH2:18][OH:19])[CH2:13]3)[CH:6]=[CH:5][C:4]=2[C:3]=1[C:24]([NH:26][CH2:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1)=[O:25]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 86609741HCID 86609741, compound

Product 1

HCID 11292966HCID 11292966, compoundYield 35.6%

Procedure

Prepared according to the method of example 33(b), using 6-chloro-N-(cyclohexylmethyl)-2-[3-[[2-[(methylsulfonyl)oxy]ethyl]amino]-1-azetidinyl]-5-quinolinecarboxamide (Example 55(a)) (0.10 g) and ethanolamine (0.3 mL) to afford the title compound (0.03 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b3e1079c3c3c4aae8bed5c83557f899d
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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