Ethanol → 2,4-Dihydro-4-(4-piperidinyl)-3H-1,2,4-triazol-3-one

Participants

Role	Name	HCID	Charge
Reactant	Ethanol	HCID 702	—
Reactant	1,4-Cyclohexadiene	HCID 12343	—
Reactant	4-(1-Benzyl-4-piperidinyl)-3,4-dihydro-2H-1,2,4-triazole-3-one	HCID 59175734	—
Catalyst	Palladium hydroxide	HCID 9942167	—
Solvent	Water	HCID 962	—
Product	2,4-Dihydro-4-(4-piperidinyl)-3H-1,2,4-triazol-3-one	HCID 68502202	50.3%

Reaction Conditions

Temperature	100 °C

Reaction Steps

2,4-Dihydro-4-[1-(phenylmethyl)-4-piperidinyl]-3H-1,2,4-triazol-3-one (Example 64(b)) (2.2 g) was divided between 2, 10 mL vials. 1,4-Cyclohexadiene (5 mL) and palladium hydroxide (270 mg, 20 wt. % on carbon) were added to each vial and the reactions were heated at 100° C. for 30 minutes within a microwave. The reaction mixtures were combined, ethanol (50 mL) and water (50 mL) were added and the mixture was filtered through diatomaceous earth and evaporated to give the sub-title compound as a solid (720 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07408065B2
Source dataset	uspto-grants-2008_08
ORD ID	ord-64fb7b54e25f48c6b0e8d4b12a465203
Source note	uspto-grants-2008_08