Methanol → N-[6-Chloro-2-[4-(1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl)-1-piperidinyl]-5-quinolinyl]-cyclohexaneacetamide

HRID 2217865Notes

Reaction equation

HRID 2217865 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:22])[C:8]=2[NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[N:3]=1.[NH:23]1[CH2:28][CH2:27][CH:26]([N:29]2[CH:33]=[N:32][NH:31][C:30]2=[O:34])[CH2:25][CH2:24]1.CO>ClCCl>[Cl:22][C:7]1[C:8]([NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([N:23]1[CH2:24][CH2:25][CH:26]([N:29]3[C:30](=[O:34])[NH:31][N:32]=[CH:33]3)[CH2:27][CH2:28]1)[CH:11]=[CH:10]2

Participants

5

Reactant 3

HCID 887MethanolHCID 68502202HCID 68502202, compoundHCID 86012996N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide

Product 1

HCID 11784646N-[6-Chloro-2-[4-(1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl)-1-piperidinyl]-5-quinolinyl]-cyclohexaneacetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared according to the method of example 30, using N-(2,6-dichloro-5-quinolinyl)-cyclohexaneacetamide (Example 1(a)) (150 mg) and 2,4-dihydro-4(4-piperidinyl)-3H-1,2,4-triazol-3-one Example 64 (c)) (225 mg). Methanol (10 mL) and dichloromethane (10 mL) were added to the reaction mixture and the solid was collected by filtration to afford the title compound (40 mg).

Workup

  1. customPrepared
  2. filtrationthe solid was collected by filtration

Sources & evidence

ORD record
ord-8b91735eb5d14fc8be6df96734f9cdd5
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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