Ethyl 2-(piperidin-4-yl)acetate → HCID 86609742, compound

HRID 2217869Notes

Reaction equation

HRID 2217869 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:22])[C:8]=2[NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[N:3]=1.[NH:23]1[CH2:28][CH2:27][CH:26]([CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:25][CH2:24]1>>[Cl:22][C:7]1[C:8]([NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([N:23]1[CH2:28][CH2:27][CH:26]([CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:25][CH2:24]1)[CH:11]=[CH:10]2

Participants

3

Reactant 2

HCID 2760465Ethyl 2-(piperidin-4-yl)acetateHCID 86012996N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide

Product 1

HCID 86609742HCID 86609742, compoundYield 53.6%

Procedure

Prepared according to the method of example 30, using N-(2,6-dichloro-5-quinolinyl)-cyclohexaneacetamide (prepared as in Example 1(a)) (200 mg) and 4-piperidineacetic acid, ethyl ester (305 mg). The reaction mixture was evaporated to dryness, the residue was suspended in methanol and the solid collected by filtration to afford the sub-title compound (150 mg).

Workup

  1. customPrepared
  2. customThe reaction mixture was evaporated to dryness
  3. filtrationthe solid collected by filtration

Sources & evidence

ORD record
ord-f44e4483f32f4e9e80e388d2d2f6264c
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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