HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-piperidinecarboxylate → Ethyl 1-(5-amino-6-chloroquinolin-2-yl)piperidine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Reactant | 2,6-Dichloroquinolin-5-amine | HCID 24820374 | — |
| Product | Ethyl 1-(5-amino-6-chloroquinolin-2-yl)piperidine-4-carboxylate | HCID 69320002 | 71.8% |
Reaction Steps
Prepared according to the method of example 30, using 2,6-dichloroquinolin-5-amine (Example 1(d)) (800 mg) and 4-piperidinecarboxylic acid, ethyl ester (1.8 g). Purification (SiO2, miethanol:dichloromethane 1:99 as eluant) gave the sub-title compound as a solid (900 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07408065B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-5e1c6f6da2c841d0bdbd637d4977daf3 |
| Source note | uspto-grants-2008_08 |