HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexanepropanoic acid → 1-[6-Chloro-5-[(3-cyclohexyl-1-oxopropyl)amino]-2-quinolinyl]-4-piperidinecarboxylic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexanepropanoic acid | HCID 69702 | — |
| Reactant | Ethyl 1-(5-amino-6-chloroquinolin-2-yl)piperidine-4-carboxylate | HCID 69320002 | — |
| Product | 1-[6-Chloro-5-[(3-cyclohexyl-1-oxopropyl)amino]-2-quinolinyl]-4-piperidinecarboxylic acid, ethyl ester | HCID 86609745 | 84.9% |
Reaction Steps
Prepared according to the method of example 62(a), using cyclohexanepropanoic acid (280 mg) and 1-(5-amino-6-chloro-2-quinolinyl)-4-piperidinecarboxylic acid, ethyl ester (Example 77(a)) (200 mg), to afford the sub-titled compound (240 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07408065B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-404ee5d6b6ac48f0930c912d6c630ad2 |
| Source note | uspto-grants-2008_08 |