HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1-Methylcyclohexyl)acetic acid → 1-[6-Chloro-5-[[(1-methylcyclohexyl)acetyl]amino]-2-quinolinyl]-4-piperidinecarboxylic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1-Methylcyclohexyl)acetic acid | HCID 13697885 | — |
| Reactant | Ethyl 1-(5-amino-6-chloroquinolin-2-yl)piperidine-4-carboxylate | HCID 69320002 | — |
| Product | 1-[6-Chloro-5-[[(1-methylcyclohexyl)acetyl]amino]-2-quinolinyl]-4-piperidinecarboxylic acid, ethyl ester | HCID 86609746 | 70.7% |
Reaction Steps
Prepared according to the method of example 62(a), using 1-methyl-cyclohexaneacetic acid (280 mg) and 1-(5-amino-6-chloro-2-quinolinyl)-4-piperidinecarboxylic acid, ethyl ester (Example 77(a)) (200 mg), to afford the sub-titled compound (200 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07408065B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-efecbd211baa4771ad7fd3b6864c7b93 |
| Source note | uspto-grants-2008_08 |