HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 11201639, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 68811261 | HCID 68811261 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 11201639 | HCID 11201639 | 29.8% |
Reaction Steps
N-[(3S)-1-[6-Chloro-5-[(cyclohexylacetyl)amino]-2-quinolinyl]-3-pyrrolidinyl]-glycine ethyl ester (Example 85(a)) (100 mg), 1M sodium hydroxide (0.422 mL) and methanol (5 mL) were stirred for 12 hours before reaction was acidified with 1M hydrochloric acid and volatiles removed under vacuum. Purification (SiO2, 7M ammonia in methanol:methanol:dichloromethane 1:4:95) gave the title compound (0.028 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07408065B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-1c97406bce83440abc9d47f227e419af |
| Source note | uspto-grants-2008_08 |