HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → N-[2-[(3S)-3-[(2-Hydroxyethyl)amino]-1-pyrrolidinyl]-6-methyl-5-quinolinyl]-cyclohexaneacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | HCID 86609748 | HCID 86609748 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-[2-[(3S)-3-[(2-Hydroxyethyl)amino]-1-pyrrolidinyl]-6-methyl-5-quinolinyl]-cyclohexaneacetamide | HCID 11235257 | — |
Reaction Steps
Prepared according to the method of example 33(b), using N-[6-methyl-2-[(3R)-3-[(methylsulfonyl)oxy]-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide (Example 86(a)) (0.16 g), 2-amino-ethanol (0.065 mL), and acetonitrile (4 mL). Purification (SiO2, 7M ammonia in methanol:methanol:dichloromethane 1:2:99 as eluant) gave the title compound (0.06 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07408065B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-ed072c71a0ac467793eef89667076807 |
| Source note | uspto-grants-2008_08 |