HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 55287554, compound → HCID 68809044, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 55287554 | HCID 55287554 | — |
| Reactant | N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide | HCID 86012996 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 68809044 | HCID 68809044 | 47.9% |
Reaction Steps
N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide (Example 1 (a)) (0.4 g), 3-[(3S)-3-pyrrolidinylamino]-propanenitrile (Example 87(a)) (0.3 g) and triethylamine (0.6 mL) were heated within a microwave in a sealed 10 mL vial for 60 minutes at 120° C. The volatiles were removed under vacuum and the mixture purified (SiO2, methanol:dichloromethane 1:99 as eluant) to give the sub-titled compound (0.25 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07408065B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-d83bffeb57414a9788076d6452d6f211 |
| Source note | uspto-grants-2008_08 |