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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2217891Generated: November 3, 2026

HCID 55287554, compound → HCID 68809044, compound

https://huagongshe.com/reaction/2217891

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 55287554HCID 55287554—
ReactantN-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamideHCID 86012996—
SolventTriethylamineHCID 8471—
ProductHCID 68809044HCID 6880904447.9%

Reaction Steps

N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide (Example 1 (a)) (0.4 g), 3-[(3S)-3-pyrrolidinylamino]-propanenitrile (Example 87(a)) (0.3 g) and triethylamine (0.6 mL) were heated within a microwave in a sealed 10 mL vial for 60 minutes at 120° C. The volatiles were removed under vacuum and the mixture purified (SiO2, methanol:dichloromethane 1:99 as eluant) to give the sub-titled compound (0.25 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07408065B2
Source datasetuspto-grants-2008_08
ORD IDord-d83bffeb57414a9788076d6452d6f211
Source noteuspto-grants-2008_08