Water → HCID 11340110, compound

Participants

Reaction Steps

N-[6-Chloro-2-[(3S)-3-[(2-cyanoethyl)amino]-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide (0.1 g), potassium hydroxide (0.051 g), water (1 mL) and methanol (2 mL) were heated within a single mode microwave in a sealed 10 mL vial for 100 minutes at 90° C. The resulting mixture was dissolved in methanol (20 mL) and purified on a Varian® SCX cartridge, washed with methanol (50 mL) and eluted with ammonia in methanol (0.7M, 50 mL). The residue was further purified on a Varian® NH2 cartridge washed with methanol (50 mL) and eluted with acetic acid:methanol (10:90). The solvent was removed under vacuum and the residue triturated with hot methanol, cooled and filtered to afford the title compound (7 mg).

Provenance & Evidence