HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[2-(3-Amino-1-pyrrolidinyl)-6-chloro-5-quinolinyl]-cyclohexanepropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (3S)-(-)-3-Aminopyrrolidine | HCID 1519351 | — |
| Reactant | N-(2,6-Dichloro-5-quinolinyl)-cyclohexanepropanamide | HCID 86012849 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-[2-(3-Amino-1-pyrrolidinyl)-6-chloro-5-quinolinyl]-cyclohexanepropanamide | HCID 68810225 | 84% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
N-(2,6-Dichloro-5-quinolinyl)-cyclohexanepropanamide (Example 90(a)) (0.24 g), (S)-3-aminopyrrolidine (0.18 g) and triethylamine (0.1 mL) were suspended in acetonitrile and heated at 100° C. in a microwave for 1 hour. The resulting precipitate was filtered and then washed with acetonitrile to give a brown solid. Purification (SiO2, methanol:dichloromethane:triethylamine 3:97:0.5) gave the title compound as a colourless solid (230 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07408065B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-087eaf8028604cbf97a30287ae4175d9 |
| Source note | uspto-grants-2008_08 |