HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium cyanide → N-[6-Chloro-2-[(3R)-3-cyano-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium cyanide | HCID 75478 | — |
| Reactant | N-[6-Chloro-2-[(3S)-3-[(methylsulfonyl)oxy]-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide | HCID 86609739 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[6-Chloro-2-[(3R)-3-cyano-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide | HCID 68809670 | — |
Reaction Steps
Prepared according to the method of example 96, using N-[6-chloro-2-[(3S)-3-[(methylsulfonyl)oxy]-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide (example 33 (a)) (0.33 g) and lithium cyanide in N,N-dimethylformamide (6 mL, 0.5M). Purification (SiO2, isohexane:ethyl acetate 60:40, as eluant) gave the sub-title compound as a solid (0.066 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07408065B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-e6961eb50cab4ed9b4b4a78e4431c9cd |
| Source note | uspto-grants-2008_08 |