Dibutyltin oxide → HCID 59768614, compound

Participants

Reaction Steps

N-[6-Chloro-2-[(3S)-3-[(2-cyanoethyl)amino]-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide (example 87 (b)) (0.15 g), trimethylsilylazide (0.091 ml), dibutyltin oxide (0.009 g) and toluene (5 ml) were heated within a single mode microwave in a sealed 10 ml vial at 100° C. for 30 minutes and then at 120° C. for 120 minutes. The reaction was cooled to room temperature, filtered and washed with toluene. The solid was then triturated with methanol and filtered before being dissolved in hot methanol and purified by Varian SCX cartridge (methanol (50 ml) and then ammonia in methanol (0.7M, 50 ml) as eluant). to afford the title compound (0.025 g).

Provenance & Evidence