HCID 55299029, compound → HCID 68808732, compound

HRID 2217913Notes

Reaction equation

HRID 2217913 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:22])[C:8]=2[NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[N:3]=1.[NH:23]1[CH2:27][CH2:26][C@H:25]([O:28][CH2:29][CH2:30][C:31]#[N:32])[CH2:24]1>>[Cl:22][C:7]1[C:8]([NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([N:23]1[CH2:27][CH2:26][C@H:25]([O:28][CH2:29][CH2:30][C:31]#[N:32])[CH2:24]1)[CH:11]=[CH:10]2

Participants

3

Reactant 2

HCID 55299029HCID 55299029, compoundHCID 86012996N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide

Product 1

HCID 68808732HCID 68808732, compoundYield 70.7%

Procedure

Prepared according to the method of example 30, using N-(2,6-dichloro-5-quinolinyl)-cyclohexaneacetamide (prepared as in Example 1(a)) (400 mg) and 3-[(3S)-3-pyrrolidinyloxy]-propanenitrile (Example 107 (b)) (350 mg). The resulting precipitate was collected by filtration and washed with acetonitrile to give the sub-title compound as a solid (370 mg).

Workup

  1. customPrepared
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with acetonitrile

Sources & evidence

ORD record
ord-3a6bbb8b10654720a09ea7a066a74ae8
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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