HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Piperidinecarbonitrile hydrochloride → 6-Chloro-2-(4-cyano-1-piperidinyl)-N-(2-cyclohexylethyl)-5-quinolinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Piperidinecarbonitrile hydrochloride | HCID 22744637 | — |
| Reactant | 2,6-Dichloro-N-(2-cyclohexylethyl)-5-quinolinecarboxamide | HCID 86012861 | — |
| Product | 6-Chloro-2-(4-cyano-1-piperidinyl)-N-(2-cyclohexylethyl)-5-quinolinecarboxamide | HCID 68809649 | 28.3% |
Reaction Steps
Prepared according to the method of example 51, using 2,6-dichloro-N-(cyclohexylethyl)-5-quinolinecarboxamide (Example 94 (d)) (0.35 g), and 4-cyanopiperidine hydrochloride (0.25 g) to afford the title compound (0.12 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07408065B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-80495ad9d07746538a204bcee4b5025c |
| Source note | uspto-grants-2008_08 |