4-Pyridinemethanamine → HCID 58874471, compound

Participants

Reaction Steps

4-Fluoro-3-nitro-N,N-bis(2,2,2-trifluoroethyl)benzamide (120 mg, 0.345 mmol) and 4-(aminomethyl)pyridine (0.070 mL, 0.380 mmoL) were stirred in 3 mL of CH3CN. The solvent was concentrated. The residue was dissolved in EtOAc and washed with saturated NaHCO3, brine and dried over anhydrous Na2SO4. The product was purified by flash chromatography on silica gel using EtOAc as eluent affording the title compound as yellow oil. Yield: 145 mg (79%); 1H NMR (CDCl3) 4.19 (q, J=8.59 Hz, 4H), 4.71 (d, J=6.25 Hz, 2H), 6.69 (d, J=8.79 Hz, 1H), 7.45 (m, 3H), 8.32 (s, 1H), 8.65 (d, J=6.25 Hz, 2H), 8.73 (m, 1H); MS (ESI) 437.24 (MH+).

Provenance & Evidence