L-Glutamine, N2-((1,1-dimethylethoxy)carbonyl)- → HCID 178503703, compound

HRID 2217953Notes

Reaction equation

HRID 2217953 reaction equation
[NH2:1][C@H:2]([C:10]([N:12]1[CH2:100][CH2:99][CH2:98][C@H:13]1[C:14]([NH:16][C@H:17]([C:25]([NH:27][C@H:28]([C:33]([NH:35][C@H:36]([C:39]([NH:41][C@H:42]([C:49]([NH:51][C@H:52]([C:58]([NH:60][CH2:61][C:62]([N:64]1[CH2:97][CH2:96][CH2:95][C@H:65]1[C:66]([NH:68][C@H:69]([C:74]([N:76]1[CH2:94][CH2:93][CH2:92][C@H:77]1[C:78]([NH:80][C@H:81]([C:89]([OH:91])=[O:90])[CH2:82][C:83]1[CH:88]=[CH:87][CH:86]=[CH:85][CH:84]=1)=[O:79])=[O:75])[CH2:70][CH2:71][S:72][CH3:73])=[O:67])=[O:63])=[O:59])[CH2:53][CH2:54][CH2:55][CH2:56][NH2:57])=[O:50])[CH2:43][C:44]1[N:48]=[CH:47][NH:46][CH:45]=1)=[O:40])[CH2:37][OH:38])=[O:34])[CH2:29][CH:30]([CH3:32])[CH3:31])=[O:26])[CH2:18][CH2:19][CH2:20][NH:21][C:22](=[NH:24])[NH2:23])=[O:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].[NH:101](C(OC(C)(C)C)=O)[C@H:102]([C:108](O)=[O:109])[CH2:103][CH2:104][C:105](=[O:107])[NH2:106]>>[NH2:101][C@H:102]([C:108]([NH:1][C@H:2]([C:10]([N:12]1[CH2:100][CH2:99][CH2:98][C@H:13]1[C:14]([NH:16][C@H:17]([C:25]([NH:27][C@H:28]([C:33]([NH:35][C@H:36]([C:39]([NH:41][C@H:42]([C:49]([NH:51][C@H:52]([C:58]([NH:60][CH2:61][C:62]([N:64]1[CH2:97][CH2:96][CH2:95][C@H:65]1[C:66]([NH:68][C@H:69]([C:74]([N:76]1[CH2:94][CH2:93][CH2:92][C@H:77]1[C:78]([NH:80][C@H:81]([C:89]([OH:91])=[O:90])[CH2:82][C:83]1[CH:88]=[CH:87][CH:86]=[CH:85][CH:84]=1)=[O:79])=[O:75])[CH2:70][CH2:71][S:72][CH3:73])=[O:67])=[O:63])=[O:59])[CH2:53][CH2:54][CH2:55][CH2:56][NH2:57])=[O:50])[CH2:43][C:44]1[N:48]=[CH:47][NH:46][CH:45]=1)=[O:40])[CH2:37][OH:38])=[O:34])[CH2:29][CH:30]([CH3:31])[CH3:32])=[O:26])[CH2:18][CH2:19][CH2:20][NH:21][C:22](=[NH:23])[NH2:24])=[O:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9])=[O:109])[CH2:103][CH2:104][C:105](=[O:107])[NH2:106]

Participants

3

Reactant 2

HCID 83687L-Glutamine, N2-((1,1-dimethylethoxy)carbonyl)-HCID 178503704HCID 178503704, compound

Product 1

HCID 178503703HCID 178503703, compound

Procedure

The resin of Example 25 was further condensed with Boc-Gln, followed by the same treatment and purification procedure and lyophilization from diluted aqueous hydrochloric acid, to give 21 mg of a white powder.

Workup

  1. customfollowed by the same treatment and purification procedure and lyophilization from diluted aqueous hydrochloric acid

Sources & evidence

ORD record
ord-9a1220e1f0024a079585c9907c700141
Source dataset
uspto-grants-2008_08
Patent number
US07410776B2

Reaction notes

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