L-Ornithine, N2-[(1,1-dimethylethoxy)carbonyl]-N5-[imino[[(4-methylphenyl)sulfonyl]amino]methyl]- → HCID 131726989, compound

HRID 2217954Notes

Reaction equation

HRID 2217954 reaction equation
[NH2:1][C@H:2]([C:8]([NH:10][C@H:11]([C:19]([N:21]1[CH2:109][CH2:108][CH2:107][C@H:22]1[C:23]([NH:25][C@H:26]([C:34]([NH:36][C@H:37]([C:42]([NH:44][C@H:45]([C:48]([NH:50][C@H:51]([C:58]([NH:60][C@H:61]([C:67]([NH:69][CH2:70][C:71]([N:73]1[CH2:106][CH2:105][CH2:104][C@H:74]1[C:75]([NH:77][C@H:78]([C:83]([N:85]1[CH2:103][CH2:102][CH2:101][C@H:86]1[C:87]([NH:89][C@H:90]([C:98]([OH:100])=[O:99])[CH2:91][C:92]1[CH:97]=[CH:96][CH:95]=[CH:94][CH:93]=1)=[O:88])=[O:84])[CH2:79][CH2:80][S:81][CH3:82])=[O:76])=[O:72])=[O:68])[CH2:62][CH2:63][CH2:64][CH2:65][NH2:66])=[O:59])[CH2:52][C:53]1[N:57]=[CH:56][NH:55][CH:54]=1)=[O:49])[CH2:46][OH:47])=[O:43])[CH2:38][CH:39]([CH3:41])[CH3:40])=[O:35])[CH2:27][CH2:28][CH2:29][NH:30][C:31](=[NH:33])[NH2:32])=[O:24])=[O:20])[CH2:12][CH2:13][CH2:14][NH:15][C:16](=[NH:18])[NH2:17])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].[NH:110]([C:132]([O:134]C(C)(C)C)=O)[C@H:111]([C:129]([OH:131])=O)[CH2:112][CH2:113][CH2:114][NH:115][C:116](=[NH:128])[NH:117]S(C1C=CC(C)=CC=1)(=O)=O>>[NH2:10][C@H:11]([C:132]([NH:110][C@H:111]([C:129]([NH:1][C@H:2]([C:8]([NH:10][C@H:11]([C:19]([N:21]1[CH2:109][CH2:108][CH2:107][C@H:22]1[C:23]([NH:25][C@H:26]([C:34]([NH:36][C@H:37]([C:42]([NH:44][C@H:45]([C:48]([NH:50][C@H:51]([C:58]([NH:60][C@H:61]([C:67]([NH:69][CH2:70][C:71]([N:73]1[CH2:106][CH2:105][CH2:104][C@H:74]1[C:75]([NH:77][C@H:78]([C:83]([N:85]1[CH2:103][CH2:102][CH2:101][C@H:86]1[C:87]([NH:89][C@H:90]([C:98]([OH:100])=[O:99])[CH2:91][C:92]1[CH:93]=[CH:94][CH:95]=[CH:96][CH:97]=1)=[O:88])=[O:84])[CH2:79][CH2:80][S:81][CH3:82])=[O:76])=[O:72])=[O:68])[CH2:62][CH2:63][CH2:64][CH2:65][NH2:66])=[O:59])[CH2:52][C:53]1[N:57]=[CH:56][NH:55][CH:54]=1)=[O:49])[CH2:46][OH:47])=[O:43])[CH2:38][CH:39]([CH3:41])[CH3:40])=[O:35])[CH2:27][CH2:28][CH2:29][NH:30][C:31](=[NH:32])[NH2:33])=[O:24])=[O:20])[CH2:12][CH2:13][CH2:14][NH:15][C:16](=[NH:17])[NH2:18])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6])=[O:131])[CH2:112][CH2:113][CH2:114][NH:115][C:116](=[NH:128])[NH2:117])=[O:134])[CH2:12][CH2:13][CH2:14][NH:15][C:16](=[NH:17])[NH2:18]

Participants

3

Reactant 2

HCID 83767L-Ornithine, N2-[(1,1-dimethylethoxy)carbonyl]-N5-[imino[[(4-methylphenyl)sulfonyl]amino]methyl]-HCID 178503703HCID 178503703, compound

Product 1

HCID 131726989HCID 131726989, compound

Procedure

The resin of Example 26 was further condensed with Boc-Arg(Tos) two times, followed by the same treatment and purification procedure, to give 17 mg of a white powder.

Workup

  1. customfollowed by the same treatment and purification procedure

Sources & evidence

ORD record
ord-fc19da3ee6b1481aa1b9271b1f68a73b
Source dataset
uspto-grants-2008_08
Patent number
US07410776B2

Reaction notes

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