HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Cesium fluoride → 3-Methoxy-5-phenylpyrazin-2-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Cesium fluoride | HCID 25953 | — |
| Edukt | Phenylboronic Acid | HCID 66827 | — |
| Edukt | 2-Amino-5-bromo-3-methoxypyrazine | HCID 11344724 | — |
| Katalysator | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 3-Methoxy-5-phenylpyrazin-2-amine | HCID 11030863 | 81,8% |
Reaktionsschritte
5-Bromo-3-methoxy-2-pyrazinamine (0.31 g), cesium fluoride (0.8 g), benzeneboronic acid (0.36 g) and [1,1′-bis(diphenylphosphino)ferrocene]palladium (II) chloride (0.08 g) in methanol (7 mL) was heated at reflux for 2 hours. The solvent was evaporated and the residue purified by chromatography on silica eluting with toluene/ethyl acetate mixtures to give the sub-title compound (0.25 g).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07410972B2 |
| Quelldatensatz | uspto-grants-2008_08 |
| ORD ID | ord-34439772743d4c6d956934e77180548d |
| Quellennotiz | uspto-grants-2008_08 |