HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-Bromo-3-phenoxypyrazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Amino-3,5-dibromopyrazine | HCID 620004 | — |
| Reactant | Sodium Phenoxide Trihydrate | HCID 23681143 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-Bromo-3-phenoxypyrazin-2-amine | HCID 17956021 | — |
Reaction Steps
Sodium phenoxide trihydrate (0.5 g) and 3,5-dibromo-2-pyrazinamine (0.5 g) in acetonitrile (20 mL) were heated at reflux for 7 hours. After cooling, water was added and the reaction mixture extracted with ethyl acetate (x2). The combined extracts were dried (MgSO4) and the solvent evaporated to give the sub-title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07410972B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-5108105ed69245bb8a1aa50a4ef0b6f7 |
| Source note | uspto-grants-2008_08 |