3-Pyridinemethanol → 5-Chloro-N-[5-methyl-3-(3-pyridinylmethoxy)-2-pyrazinyl]-2-thiophenesulphonamide

HRID 2217979Notes

Reaction equation

HRID 2217979 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][OH:8])[CH:2]=1.[Cl:9][C:10]1[S:14][C:13]([S:15]([NH:18][C:19]2[C:24](Br)=[N:23][C:22]([CH3:26])=[CH:21][N:20]=2)(=[O:17])=[O:16])=[CH:12][CH:11]=1>>[Cl:9][C:10]1[S:14][C:13]([S:15]([NH:18][C:19]2[C:24]([O:8][CH2:7][C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)=[N:23][C:22]([CH3:26])=[CH:21][N:20]=2)(=[O:16])=[O:17])=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 75103-PyridinemethanolHCID 103092085-Chloro-N-(3-bromo-5-methyl-2-pyrazinyl)-2-thiophenesulphonamide

Product 1

HCID 99306625-Chloro-N-[5-methyl-3-(3-pyridinylmethoxy)-2-pyrazinyl]-2-thiophenesulphonamide

Procedure

Prepared by the method of Example 20b using pyridine-3-methanol and 5-chloro-N-(3-bromo-5-methyl-2-pyrazinyl)-2-thiophenesulphonamide.

Workup

  1. customPrepared by the method of Example 20b

Sources & evidence

ORD record
ord-bb81cbc856e448fca9cf8fa5f84ef2a0
Source dataset
uspto-grants-2008_08
Patent number
US07410972B2

Reaction notes

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