Citric Acid → HCID 10125594, compound

Participants

Reaction Steps

5-Chloro-N-(3-chloro-2-pyrazinyl)-2-thiophenesulphonamide (Example 25a) (0.03 g) in sodium methoxide in methanol (1.5 mL of a 10% solution) was heated at 85° C. After 4 h, 5% aqueous citric acid (10.0 mL) was added and the mixture extracted with ethyl acetate (2×30 mL). The combined extracts were washed with brine, dried (MgSO4) and the solvent evaporated. Chromatography on silica gel eluting with ethyl acetate/isohexane mixtures gave the title compound as a white solid (0.026 g).

Provenance & Evidence