Methyl acetoacetate → HCID 178429300, compound

Participants

Reaction Conditions

Reaction Steps

2.00 g (7.43 mmol) of 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide (example I, step 5) are dissolved together with 1.04 g (8.91 mmol) of methyl 3-oxobutanoate in 10 ml of absolute toluene under argon and stirred under reflux for 8 hours. A further 8.91 mmol of methyl 3-oxobutanoate are added, and stirring under reflux temperature is continued for 24 hours. This is followed by cooling to 0° C., removal of the precipitated solid by filtration and drying under high vacuum. 1.98 g (72% of theory) of the product are obtained.

Provenance & Evidence