Sodium Carbonate → HCID 11544891, compound

Participants

Reaction Conditions

Reaction Steps

300 mg (0.90 mmol) of 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methyl-4-pyrimidinol (example I, step 6) are suspended in 2 ml of phosphoryl chloride and stirred at 100° C. After the reaction is complete, a concentrated aqueous sodium carbonate solution is added, and the mixture is extracted with diethyl ether. The organic phase is dried over magnesium sulfate and filtered, and the solvent is removed in vacuo. 256 mg (77% of theory) of the product are obtained.

Provenance & Evidence