Furan-2-boronic acid → HCID 11267838, compound

HRID 2218020Notes

Reaction equation

HRID 2218020 reaction equation
I[C:2]1[CH:22]=[CH:21][C:5]2[N:6]([CH3:20])[C:7](=[O:19])[CH2:8][N:9]=[C:10]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])[C:4]=2[CH:3]=1.[O:23]1[CH:27]=[CH:26][CH:25]=[C:24]1B(O)O>>[O:23]1[CH:27]=[CH:26][CH:25]=[C:24]1[C:2]1[CH:22]=[CH:21][C:5]2[N:6]([CH3:20])[C:7](=[O:19])[CH2:8][N:9]=[C:10]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 2734357Furan-2-boronic acidHCID 69289094HCID 69289094, compound

Product 1

HCID 11267838HCID 11267838, compoundYield 8%

Procedure

Prepared from 3-(7-iodo-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile Intermediate 11 using the same conditions used to prepare Example 1 but using 2-furanboronic acid instead of benzene boronic acid. The title compound (10 mg) was obtained as a brown solid, (yield=8%).

Workup

  1. customto prepare Example 1

Sources & evidence

ORD record
ord-f4a7da9f3b8843b7ab342fed327d2124
Source dataset
uspto-grants-2008_08
Patent number
US07410963B2

Reaction notes

Loading…