3,4-Dimethoxyphenylboronic acid → HCID 11464049, compound

HRID 2218021Notes

Reaction equation

HRID 2218021 reaction equation
I[C:2]1[CH:22]=[CH:21][C:5]2[N:6]([CH3:20])[C:7](=[O:19])[CH2:8][N:9]=[C:10]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])[C:4]=2[CH:3]=1.[CH3:23][O:24][C:25]1[CH:26]=[C:27](B(O)O)[CH:28]=[CH:29][C:30]=1[O:31][CH3:32]>>[CH3:23][O:24][C:25]1[CH:26]=[C:27]([C:2]2[CH:22]=[CH:21][C:5]3[N:6]([CH3:20])[C:7](=[O:19])[CH2:8][N:9]=[C:10]([C:11]4[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=4)[C:14]#[N:15])[C:4]=3[CH:3]=2)[CH:28]=[CH:29][C:30]=1[O:31][CH3:32]

Participants

3

Reactant 2

HCID 27347023,4-Dimethoxyphenylboronic acidHCID 69289094HCID 69289094, compound

Product 1

HCID 11464049HCID 11464049, compoundYield 72%

Procedure

Prepared from 3-(7-iodo-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile Intermediate 11 using the same conditions used to prepare Example 1 but using 3,4-dimethoxyphenyl boronic acid instead of benzene boronic acid. The title compound (110 mg) was obtained as a beige solid, (yield=72%).

Workup

  1. customto prepare Example 1

Sources & evidence

ORD record
ord-8975468ec67d4027ae1717c4912c4eb1
Source dataset
uspto-grants-2008_08
Patent number
US07410963B2

Reaction notes

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