(2-Phenoxyphenyl)boronic acid → HCID 57478645, compound

HRID 2218032Notes

Reaction equation

HRID 2218032 reaction equation
I[C:2]1[CH:22]=[CH:21][C:5]2[N:6]([CH3:20])[C:7](=[O:19])[CH2:8][N:9]=[C:10]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])[C:4]=2[CH:3]=1.[O:23]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1B(O)O)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH3:20][N:6]1[C:5]2[CH:21]=[CH:22][C:2]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[O:23][C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)=[CH:3][C:4]=2[C:10]([C:11]2[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=2)[C:14]#[N:15])=[N:9][CH2:8][C:7]1=[O:19]

Participants

3

Reactant 2

HCID 2773559(2-Phenoxyphenyl)boronic acidHCID 69289094HCID 69289094, compound

Product 1

HCID 57478645HCID 57478645, compoundYield 41%

Procedure

Prepared from 3-(7-iodo-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile Intermediate 11 using the same conditions used to prepare Example 1 but using 2-phenoxy-phenyl boronic acid instead of benzene boronic acid. The title compound (90 mg) was obtained as a beige solid, in 41% yield.

Workup

  1. customto prepare Example 1

Sources & evidence

ORD record
ord-930748f92ac94464b686708cf3cb039a
Source dataset
uspto-grants-2008_08
Patent number
US07410963B2

Reaction notes

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