HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-1-iodo-3-phenyl-3-propanol → (1R)-4-Fluoro-7-(3-iodo-1-phenyl-propoxy)-2,3-dihydrobenzo[b]thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-1-iodo-3-phenyl-3-propanol | HCID 14476876 | — |
| Reactant | HCID 17981923 | HCID 17981923 | — |
| Product | (1R)-4-Fluoro-7-(3-iodo-1-phenyl-propoxy)-2,3-dihydrobenzo[b]thiophene | HCID 58612390 | — |
Reaction Steps
using (S)-1-iodo-3-phenyl-3-propanol with 4-fluoro-2,3-dihydrobenzo[b]thiophen-7-ol, to give 243 mg of the title compound as a colourless solid: δH (300 MHz, CDCl3) 7.32-7.12 (5H, m, 3-ArH), 6.46-6.27 (3H, m, ArH), 5.15-5.06 (1H, m, CHO), 3.43-3.11 (6H, m CH2CH2HI and SCH2CH2), 2.50-2.31 (1H, m, CHHCH2I) and 2.27-2.09 (1H, m, CHHCH2I).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07410982B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-bee28b402d5b46a6a61de23fb34f327f |
| Source note | uspto-grants-2008_08 |