Sodium Iodide → HCID 58612381, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-[(1R)-(3-Chloro-1-phenyl-propoxy)]-thieno[3,2-b]pyridine (703 mg, 2.3 mmol) in 15 mL of acetone was added NaI (3.5 g, 23 mmol). The resulting solution was allowed to stir at 55° C. for 18 h before removing the acetone in vacuo. The residue was taken up in CH2Cl2 and water. The layers were separated and the aqueous phase was further extracted 2 times with CH2Cl2. The combined organic phase was dried (MgSO4) and concentrated in vacuo. The residue was purified by flash chromatography eluting silica gel with hexane:ethyl acetate [100:0 to 1:1] to yield the title compound (0.79 g, 87%); mass spectrum (ion spray): m/z=395.98 (m+1).

Provenance & Evidence