HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2218110Generated: October 30, 2026
Methylamine → 3-(benzyloxy)-N-cyclobutyl-1,6-dimethyl-4-oxo-1,4-dihydropyridine-2-carboxamide
https://huagongshe.com/reaction/2218110
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 3-(benzyloxy)-N-cyclobutyl-6-methyl-4-oxo-4H-pyran-2-carboxamide | HCID 86611798 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(benzyloxy)-N-cyclobutyl-1,6-dimethyl-4-oxo-1,4-dihydropyridine-2-carboxamide | HCID 66658948 | 62.4% |
Reaction Steps
To a solution of the compound from example 4 (2.616 g, 8.35 mmol, 1.0 equiv) in methanol (10 ml) was quickly added methylamine (2M in methanol, 20 ml, 40 mmol, 4.79 equiv). The sealed tube was stirred overnight at 70-75° C. The resulting brown solution was evaporated to dryness and purified by chromatography (EtOAc, then 1:4 MeOH/EtOAc) provided the titled compound (1.70 g, 62.24%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07410985B2 |
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| Source dataset | uspto-grants-2008_08 |
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| ORD ID | ord-2fb4e02112ed4d7e85f815f86e6835af |
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| Source note | uspto-grants-2008_08 |
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