Lithium Hydroxide → HCID 10323518, compound

Participants

Reaction Conditions

Reaction Steps

(±)-3-(4-{2-Oxo-3-[4-(3-o-tolyl-ureido)phenyl]-2H-pyridin-1-ylmethyl}phenyl)-butyric acid methyl ester (0.21 g, 0.41 mmol) was dissolved in tetrahydrofuran (3 mL) and aqueous lithium hydroxide (0.5 M, 3 mL) added with stirring. The mixture was heated at 65° C. for 2 hours and then allowed to cool and concentrated in vacuo. The mixture was acidified with hydrochloric acid (2M), extracted with ethyl acetate (2×25 mL) and the combined organic layers washed with brine and dried over anhydrous magnesium sulfate. After filtration and evaporation to dryness the title compound was obtained as a white solid.

Provenance & Evidence