反应详情

A solution of 4-methoxyphenyl ethanol (15.0 g, 98.2 mmol) in 150 mL of methylene chloride was stirred at 0° C. while Dess-Martin periodinane (50 g, 1.2 eq.) was added in small portions. The ice-bath was removed and the reaction was stirred at rt for 1 h. The reaction mixture was then diluted with methylene chloride (100 mL), washed with 10% sodium thiosulfate, saturated NaHCO3 solution, water, saturated NaCl solution, and dried over Na2SO4. The product was purified using silica gel chromatography (100% hexanes to 20% EtOAC/hexanes) to afford 5.3 g (34%) of 4-methoxyphenyl acetaldehyde.

1. additionwas added in small portions
2. customThe ice-bath was removed
3. additionThe reaction mixture was then diluted with methylene chloride (100 mL)
4. washwashed with 10% sodium thiosulfate, saturated NaHCO3 solution, water, saturated NaCl solution
5. dry with materialdried over Na2SO4
6. customThe product was purified