Boron tribromide → 5-(4-Hydroxyphenyl)-2-methyl-2H-pyridazin-3-one

HRID 221816Notes

Reaction equation

C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[N:13][N:12]([CH3:15])[C:11](=[O:16])[CH:10]=2)=[CH:5][CH:4]=1.B(Br)(Br)Br>>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[N:13][N:12]([CH3:15])[C:11](=[O:16])[CH:10]=2)=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 569461985-(4-methoxy-phenyl)-2-methyl-2H-pyridazin-3-one

Product 1

HCID 569461995-(4-Hydroxyphenyl)-2-methyl-2H-pyridazin-3-one

Procedure

5-(4-Hydroxyphenyl)-2-methyl-2H-pyridazin-3-one was prepared from 5-(4-methoxy-phenyl)-2-methyl-2H-pyridazin-3-one with BBr3 using the procedure described in Example 86 Step 2; Mp 296-8° C.; MS m/z 203 (M+H).

Sources & evidence

ORD record: ord-74b38739f7a74239ab1b19a240fb3859
Source dataset: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08207168B2

Reaction notes

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