Potassium Iodide → HCID 11741533, compound

Participants

Reaction Steps

A solution of 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropyl-p-toluene sulphonate (Prepared by following the process as described in EP 0 325 571, 0.486 gm, 1 mmol), 3-azabicyclo[3.1.0]hexane hydrochloride (Prepared by following the process as described in U.S. Pat. No. 4,183,857, 0.12 gm, 1 mmol), potassium carbonate (0.275 gm, 2 mmol), potassium iodide (0.17 gm, 1 mmol) in acetonitrile (10 ml) and dimethylformamide (10 ml) were refluxed for 15 hours at about 100° C. The cooled reaction mixture was poured into water and extracted with ethyl acetate. The combined organic layers were dried over sodium sulphate and concentrated in vacuo to afford an oily residue, which was purified by column chromatography (silica gel 100-200 mesh), eluting the compound with 50-50 ethylacetate-hexane mixture.

Provenance & Evidence