Sodium Hydroxide → HCID 136114641, compound

HRID 2218257Notes

Reaction equation

HRID 2218257 reaction equation
[NH2:1][C:2]1[N:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[OH:16])[CH:7]=[C:6]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([OH:25])=[O:24])[CH:18]=2)[C:3]=1[C:4]#[N:5].[OH-].[Na+:27]>>[NH2:1][C:2]1[C:3]([C:4]#[N:5])=[C:6]([C:17]2[CH:18]=[C:19]([CH:20]=[CH:21][CH:22]=2)[C:23]([O-:25])=[O:24])[CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[OH:16])[N:9]=1.[Na+:27]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 136094896HCID 136094896, compound

Product 1

HCID 136114641HCID 136114641, compoundYield 95%

Procedure

2-amino-6-(2-hydroxyphenyl)-4-(3-hydroxycarbonyl-phenyl)nicotinonitrile (0.02 g, 0.045 mmol) was dissolved in 4N NaOH solution (2 mL), and the resulting solution was purified by HPLC (ODS reverse phase column, 10% CH3CN/H2O-90% CH3CN/H2O) to give Sodium 3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]benzoate as a pale yellow powder (0.015 g, 95%).

Workup

  1. customthe resulting solution was purified by HPLC (ODS reverse phase column, 10% CH3CN/H2O-90% CH3CN/H2O)

Sources & evidence

ORD record
ord-9ac0a96a212743d997065f50645d05e4
Source dataset
uspto-grants-2008_08
Patent number
US07410986B2

Reaction notes

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