HRID2218295

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57440892

1-Cyclopropyl-5-methoxyisoquinoline-7-carboxylic acid

C14H13NO3

结构：Cl.Cl.NC(=O)c1cncc(-c2ccc3c(c2)C(=O)CC2(CCNCC2)O3)c1

HCID66782039

未命名化合物

HCID67170213

8-Cyclopropyl-4-(2-hydroxyethoxy)-1,7-naphthyridine-2-carboxylic acid

C14H14N2O4

PRODUCTS

生成物

结构：NC(=O)c1cncc(-c2ccc3c(c2)C(=O)CC2(CCN(C(=O)c4cc(OCCO)c5ccnc(C6CC6)c5n4)CC2)O3)c1

HCID16042869

未命名化合物

PROCEDURE

实验过程

The intended compound was produced according to the procedure described in reference Example 37 but using 5-{4-oxospiro[chroman-2,4′-piperidin]-6-yl}nicotinamide di-hydrochloride and 8-cyclopropyl-4-(2-hydroxy-ethoxy)-[1,7]naphthyridine-2-carboxylic acid in place of methyl 5-{4-oxospiro[chroman-2,4′-piperidin]-6-yl}nicotinate di-hydrochloride and 1-cyclopropyl-5-methoxyisoquinoline-7-carboxylic acid.

WORKUP

后处理

customThe intended compound was produced

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-46c0a67825fa42aaba6e0277c72b72d6
来源数据集: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07410976B2
来源说明: uspto-grants-2008_08

反应 SMILES

Cl.Cl.[O:3]=[C:4]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:19]3[CH:20]=[N:21][CH:22]=[C:23]([CH:27]=3)[C:24]([NH2:26])=[O:25])[CH:17]=2)[O:12][C:6]2([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5]1.[CH:28]1([C:31]2[N:32]=[CH:33][CH:34]=[C:35]3[C:40]=2[N:39]=[C:38]([C:41](O)=[O:42])[CH:37]=[C:36]3[O:44][CH2:45][CH2:46][OH:47])[CH2:30][CH2:29]1.C1(C2C3C(=C(OC)C=C(C(O)=O)C=3)C=CN=2)CC1>>[CH:28]1([C:31]2[N:32]=[CH:33][CH:34]=[C:35]3[C:40]=2[N:39]=[C:38]([C:41]([N:9]2[CH2:10][CH2:11][C:6]4([CH2:5][C:4](=[O:3])[C:18]5[C:13](=[CH:14][CH:15]=[C:16]([C:19]6[CH:20]=[N:21][CH:22]=[C:23]([CH:27]=6)[C:24]([NH2:26])=[O:25])[CH:17]=5)[O:12]4)[CH2:7][CH2:8]2)=[O:42])[CH:37]=[C:36]3[O:44][CH2:45][CH2:46][OH:47])[CH2:29][CH2:30]1