Hydrochloric Acid → HCID 16041044, compound

Participants

Reaction Steps

The free form of the compound was prepared according to the procedure described in Example 30 but using 6-amino-1′-[(4,8-dimethoxyquinolin-2-yl)carbonyl]spiro[chroman-2,4′-piperidin]-4-one and methyl chloroformate instead of 6-(piperazin-1-yl)-1′-[(4,8-dimethoxyquinolin-2-yl)carbonyl]spiro[chroman-2,4′-piperidin]-4-one and Ac2O. Then the material was converted to HCl salt according to the procedure described in Example 2. 1H-NMR (400 MHz, DMSO-d6) δ: 9.65 (1H, s), 7.84 (1H, s), 7.73-7.53 (3H, m), 7.36-7.25 (2H, m), 7.06 (1H, d, J=9.0 Hz), 4.34-4.18 (1H, m), 4.10 (3H, s), 3.97 (3H, s), 3.69-3.26 (3H, m), 3.64 (3H, s), 2.86 (2H, s), 2.10-1.71 (4H, m). MS [M+H]+=506.

Provenance & Evidence