反应详情

温度

155 °C

2-[1-(2-Cyclopropyl-pyridin-3-yl)-methylidene]-succinic acid 1-methyl ester (18.9 g, 72.4 mmol), sodium acetate (5.94 g, 72.4 mmol) was suspended in AcOH (150 ml) and heated at 155° C. for 6 h. After cooling to room temperature, the mixture was concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane/EtOAc=10/0 to 6/4) to obtain the intended compound as a pale yellow solid.

1. temperatureAfter cooling to room temperature
2. concentrationthe mixture was concentrated in vacuo
3. customThe residue was purified by silica gel column chromatography (hexane/EtOAc=10/0 to 6/4)