Methyl iodide → 8-Cyclopropyl-4-(2-hydroxyethoxy)-1,7-naphthyridine-2-carboxylic acid

HRID 2218316Notes

Reaction equation

HRID 2218316 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][CH:7]=[C:8]3[C:13]=2[N:12]=[C:11]([C:14]([OH:16])=[O:15])[CH:10]=[C:9]3[OH:17])[CH2:3][CH2:2]1.Br[CH2:19][CH2:20][O:21]C(=O)C.IC>>[CH:1]1([C:4]2[N:5]=[CH:6][CH:7]=[C:8]3[C:13]=2[N:12]=[C:11]([C:14]([OH:16])=[O:15])[CH:10]=[C:9]3[O:17][CH2:19][CH2:20][OH:21])[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 135641-Acetoxy-2-bromoethaneHCID 178524589HCID 178524589, compound

Product 1

HCID 671702138-Cyclopropyl-4-(2-hydroxyethoxy)-1,7-naphthyridine-2-carboxylic acid

Procedure

The intended compound was produced according to the procedures described in reference examples 35 and 36 but using 8-cyclopropyl-4-hydroxy-[1,7]naphthyridine-2-carboxylic acid and acetic acid 2-bromoethyl ester in place of 1-Cyclopropyl-5-hydroxy-isoquinoline-7-carboxylic acid methyl ester and iodomethane.

Workup

  1. customThe intended compound was produced

Sources & evidence

ORD record
ord-719b1b2e423f4babb3c8b0ff5caa064b
Source dataset
uspto-grants-2008_08
Patent number
US07410976B2

Reaction notes

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